PT-141

What it is:

PT-141 (Bremelanotide) is a synthetic cyclic heptapeptide and non-selective melanocortin receptor agonist derived from Melanotan II through structural modification involving removal of the C-terminal amide group. Its molecular formula is C50H68N14O10 with a molecular weight of 1025.2 g/mol. Unlike its parent compound Melanotan II, PT-141 lacks the acetyl group at the N-terminus, resulting in a distinct receptor interaction profile. It engages MC1R, MC3R, MC4R, and MC5R receptor subtypes with particular affinity for MC4R, making it a research tool in melanocortin receptor pharmacology, hypothalamic signaling biology, and autonomic nervous system research. It is notable in the research literature as one of the few synthetic melanocortin analogues to have progressed through formal clinical investigation pathways.