ARA-290

What it is:

ARA-290 (Cibinetide) is a synthetic 11-amino acid peptide with the sequence Gln-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser, engineered from the helix B surface region of erythropoietin (EPO). It was designed to selectively engage the innate repair receptor (IRR) — a heteromeric complex consisting of the erythropoietin receptor (EPOR) and the beta-common receptor subunit (CD131) — without activating the classical homodimeric erythropoietin receptor responsible for erythropoiesis and hematopoietic signaling. This receptor selectivity makes it a research tool for studying non-hematopoietic EPO biology, innate repair signaling pathway pharmacology, and tissue-protective receptor biology independently of erythropoietic activity.